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December 8, 2025Blood

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

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Authors

EFEmiliano FabianiFRFrancesca RomanoGOGuadalupe Oñate

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Overview

Retrospective analysis reveals FLT3-ITD microclones affect complete response rates in AML patients, suggesting diagnostic method improvements.

Key Points

  • To evaluate the diagnostic methods and prognostic implications of FLT3-ITD microclones in AML.
  • Conducted a retrospective multicenter analysis
  • Analyzed capillary electrophoresis from 63 patient samples
  • Compared NGS and capillary electrophoresis for FLT3-ITD status in 48 cases
  • Assessed interrater reliability using intraclass correlation coefficient
  • Achieved complete response in 88% of patients with FLT3-ITD AR >0.05
  • Identified significant correlation between AR/VAF as r=0.923, p<0.001
  • Older age linked to FLT3-ITD microclones, with median age 62
  • Observed 3-year overall survival of 58% in intensively treated patients

Cite This Study

Fabiani et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc4chttps://doi.org/10.1182/blood-2025-217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of initial FLT3-ITD mutated clone numbers on clinical outcomes in Acute Myeloid Leukemia2025
  2. 2Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data2025
  3. 3Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025
  4. 4DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors2025 · 2 citations
  5. 5Prognostic relevance of multiparameter flow cytometry-based MRD assessment in patients with FLT3-ITD mutated AML considering concomitant mutations including DNMT3A/NPM1/WT1 mutation2025 · 1 citations