Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors

View Full Paper
Ask AI
Bookmark
Share

Authors

SMShirley S. MoADAmy E. DeZernEFEphraim J. Fuchs

Discussion

Loading...

Member takes

Overview

Analysis shows triple mutations in AML improves overall and event-free survival with FLT3 inhibitors for better outcomes.

Key Points

  • To evaluate the outcomes of triple-mutated AML (DNMT3A/NPM1/FLT3-ITD) in the context of modern therapeutic approaches.
  • Analyzed a cohort of 431 adult patients with newly diagnosed AML treated at Johns Hopkins Hospital.
  • Conducted targeted sequencing of 60 leukemia-associated genes using genomic DNA from blood or bone marrow.
  • Reviewed clinical records for baseline characteristics, MRD status, and overall survival with FLT3 inhibitors.
  • FLT3 mutations identified in 23.4% of patients; 17% with FLT3-ITD among 431 AML cases.
  • Patients with triple mutations showed an overall survival of 82% at 2 years, whereas non-triple mutations had 50%.
  • Triple-mutated AML patients demonstrated higher MRD negativity rates and improved responsiveness to FLT3 inhibitors.

Cite This Study

Mo et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d332https://doi.org/10.1182/blood-2025-1710
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data2025
  2. 2Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)2025 · 1 citations
  3. 3Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025
  4. 4FLT3-ITD with NPM1 and/or DNMT3A co-mutations in acute myeloid leukemia: prognostic significance and the role of maintenance therapy post-transplantation2025 · 1 citations
  5. 5Outcomes of patients with newly diagnosed acute myeloid leukemia with FLT3-tyrosine kinase domain mutations: Prognostic implications of NPM1 co-mutation.2025 · 3 citations