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December 8, 2025BloodOpen Access

Autologous and allogeneic stem cell transplantation for ALK-positive anaplastic large cell lymphoma: An analysis of the EBMT lymphoma working party

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Authors

MNMaud NgoyaSCSridhar ChagantiKCKate Cwynarski

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Overview

Analysis shows autologous stem cell transplantation improves progression-free survival in ALK-positive lymphoma patients, suggesting effective consolidation strategies.

Key Points

  • This research aims to assess the outcomes of autologous and allogeneic stem cell transplantation in patients with ALK-positive anaplastic large cell lymphoma.
  • Analyzed outcomes of patients older than 18 diagnosed with ALK-positive ALCL from EBMT and Asian centers (2010-2022)
  • Compared up-front and salvage transplantation cases.
  • Tracked progression-free survival and overall survival for various therapy lines prior to transplant.
  • 282 patients underwent autologous stem cell transplantation, and 77 underwent salvage allogeneic transplantation.
  • Up-front ASCT showed a 2-year progression-free survival of 79.2% and overall survival of 91.3%.
  • Higher non-relapse mortality noted in patients with later lines of therapy prior to allo-SCT.

Cite This Study

Ngoya et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d96bhttps://doi.org/10.1182/blood-2025-891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi‐Institutional Study of <scp>ALK</scp>‐Positive Large B‐Cell Lymphoma: Outcomes in the Era of <scp>ALK</scp> Inhibitors and Biologically Informed Therapies2025 · 3 citations
  2. 2Outcomes of autologous transplant (ASCT) in patients with chemosensitive late relapse of large B-cell lymphoma (LBCL)2025
  3. 3Autologous Transplant (ASCT) in Patients with Chemosensitive Late Relapse of Diffuse Large B-Cell Lymphoma (DLBCL)2026
  4. 4Upfront allo-HSCT after intensive chemotherapy for untreated aggressive ATL: JCOG0907, a single-arm, phase 3 trial.2024 · 1 citations
  5. 5Long-Term Follow-Up of the Prospective Randomized AATT Study (Autologous or Allogeneic Transplantation in Patients With Peripheral T-Cell Lymphoma)2024 · 16 citations