What question did this study set out to answer?

Evaluate how different genotypes of sickle cell disease and severity of anemia affect myocardial extracellular volume using cardiac imaging.

December 8, 2025BloodOpen Access

Impact of disease genotype and severity of anemia on myocardial extracellular volume fraction in sickle cell disease (SCD) and non-SCD hemolytic anemias

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Evaluate how different genotypes of sickle cell disease and severity of anemia affect myocardial extracellular volume using cardiac imaging.
Studied three groups of hemolytic anemia: SS/Sβ0, SC/Sβ+, and non-SCD forms.
Used cardiac magnetic resonance imaging with gadolinium-enhanced T1 mapping to measure extracellular volume.
Measured hematocrit levels at the time of cardiac imaging.
96% of SS/Sβ0 displayed increased ECV compared to 86% in SC/Sβ+ and 58% in non-SCD.
Average ECV values were highest in SS/Sβ0 (32.2%), followed by SC/Sβ+ (28.3%) and non-SCD (26.0%).
A significant inverse correlation between hematocrit levels and ECV was found, especially in SS/Sβ0.

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Implication

Cardiac magnetic resonance imaging reveals increased myocardial extracellular volume in sickle cell disease, indicating anemia severity impacts fibrosis in hemolytic anemias.

Cite This Study

Niss et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d99f https://doi.org/10.1182/blood-2025-2957

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Implication

Cardiac magnetic resonance imaging reveals increased myocardial extracellular volume in sickle cell disease, indicating anemia severity impacts fibrosis in hemolytic anemias.

Impact of disease genotype and severity of anemia on myocardial extracellular volume fraction in sickle cell disease (SCD) and non-SCD hemolytic anemias

Key Points

Discussion

Implication

Cite This Study

Impact of disease genotype and severity of anemia on myocardial extracellular volume fraction in sickle cell disease (SCD) and non-SCD hemolytic anemias

Key Points

Discussion

Implication

Cite This Study

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