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December 8, 2025Blood

Central nervous system involvement in Mantle Cell Lymphoma: A retrospective multicenter cohort study from the spanish geltamo group

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Authors

ACAlba CabirtaAPA. Callejo PérezACAna Saus Carreres

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Overview

Retrospective cohort study reveals CNS involvement worsens treatment response and survival in mantle cell lymphoma.

Key Points

  • This study aimed to characterize CNS involvement in mantle cell lymphoma and its impact on clinical outcomes.
  • Retrospective multicenter study of 1,162 mantle cell lymphoma patients in Spain.
  • Comparison of treatment response and survival between patients with and without CNS involvement.
  • Assessment of high-risk features and their association with outcomes.
  • Multivariate analysis to determine independent prognostic factors for survival.
  • CNS involvement occurred in 5.2% of patients, negatively impacting progression-free and overall survival.
  • Patients with CNS involvement showed significantly poorer prognosis compared to those without CNS infiltration.
  • High-risk features were more common in patients with CNS involvement, influencing treatment approaches.

Cite This Study

Cabirta et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9c8https://doi.org/10.1182/blood-2025-3585
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk factors of central nervous system relapse in mantle cell lymphoma2013 · 41 citations
  2. 2Secondary central nervous system lymphoma (SCNSL) in mantle cell lymphoma (MCL): Characteristics and risk factors in a Danish nationwide population-based study.2025
  3. 3Anti-CD19 CAR-T cells for Mantle Cell Lymphoma with central nervous system involvement: A study of the french descart registry.2025
  4. 4Contemporary real-world outcomes of mantle cell lymphoma in Colombia: Results from an expanded multicenter cohort.2026
  5. 5Real-world treatment and outcomes of Mantle Cell Lymphoma in Latin America: A multinational cohort analysis2025