Why the study?
What are the risk factors for central nervous system relapse in patients with mantle cell lymphoma?
Population
142 consecutive patients with mantle cell lymphoma treated from 1980 to 2011, median age 68 years, 82%…
Design
Cohort
Follow-up
median 7.9 years
Authors
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Blastoid histology flags high CNS relapse risk in MCL; supports risk-adapted monitoring but leaves optimal prophylaxis open for prospective trials.
What are the risk factors for central nervous system relapse in patients with mantle cell lymphoma?
Blastoid histology is a significant independent risk factor for CNS relapse in mantle cell lymphoma, which carries a poor prognosis with a median survival of 6.3 months.
Conconi et al. (2013) studied this question.
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