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December 8, 2025BloodOpen Access

Real-world analysis of treatment patterns and outcomes in older patients with Acute Myeloid Leukemia (AML) in the US community oncology setting

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Authors

HEHoward EngleJEJanet L. Espirito

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Overview

Real-world data reveals targeted therapies improve outcomes in elderly AML patients, indicating shifts in treatment patterns.

Key Points

  • To evaluate treatment patterns and outcomes in older patients with Acute Myeloid Leukemia receiving non-intensive induction therapy.
  • Retrospective analysis of AML patients aged ≥70 years using electronic health records from The US Oncology Network
  • Patients diagnosed between January 1, 2015, and December 31, 2023
  • Outpatient treatment patterns evaluated for venetoclax use; Kaplan-Meier for survival outcomes.
  • Study included 1,093 patients with median overall survival of 11.0 months
  • High adoption of venetoclax with hypomethylating agents (81.2%) in outpatient settings
  • Two-year overall survival rate was 26.9%, varying by age from 31.2% to 18.3%.

Cite This Study

Engle et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9dehttps://doi.org/10.1182/blood-2025-5190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment intensity in older adults with AML: Impact of age and induction regimen on remission and survival outcomes2025
  2. 2Real-world outcomes of venetoclax-based therapy vs intensive chemotherapy in older adults with newly diagnosed Acute Myeloid Leukemia2025
  3. 3Trends on treatment patterns in patients with newly diagnosed AML: Preliminary findings from a real-world analysis.2024
  4. 4Contemporary outcomes of octa‐nonagenarians with newly diagnosed acute myeloid leukemia2025 · 4 citations
  5. 5Acute Myeloid Leukemia in Older Adults: A Comprehensive Narrative Review of Risk Stratification and Treatment Advances2026