What question did this study set out to answer?

To investigate how age and induction intensity affect remission and overall survival in older adults with AML.

December 8, 2025Blood

Treatment intensity in older adults with AML: Impact of age and induction regimen on remission and survival outcomes

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Authors

YAYzen AlmarrawiBeaumont Health AMAndrew A. MuskovitzBeaumont Health

Discussion

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Implication

Retrospective cohort study shows treatment intensity influences remission and survival in older adults with AML, indicating potential benefits of tailored approaches.

Key Points

To investigate how age and induction intensity affect remission and overall survival in older adults with AML.
Conducted a retrospective cohort study of 152 adult patients diagnosed with AML.
Stratified patients by age (≤60 vs >60 years) and induction regimen (Anthracycline+Cytarabine vs Venetoclax+Azacitidine).
Assessed overall survival using Kaplan-Meier estimates and performed multivariable Cox regression for survival analysis.
Median overall survival (OS) for age >60 was 22.3 months, and for Ven+Aza it was 19.2 months with p=0.003.
Remission rates were significantly higher at 68.97% for Anthra+Cyt compared to 27.50% for Ven+Aza in patients >60.
Poor-risk cytogenetics were associated with a higher hazard ratio for worse overall survival.

Cite This Study

Almarrawi et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5b8 https://doi.org/10.1182/blood-2025-6907

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Implication

Retrospective cohort study shows treatment intensity influences remission and survival in older adults with AML, indicating potential benefits of tailored approaches.

Treatment intensity in older adults with AML: Impact of age and induction regimen on remission and survival outcomes

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment intensity in older adults with AML: Impact of age and induction regimen on remission and survival outcomes

Discussion

Member takes

Implication

Key Points

Cite This Study

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