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December 8, 2025BloodOpen Access

Clinical analysis of central nervous system leukemia in patients with Acute Myeloid Leukemia

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Authors

JWJunqing WuCell Technology (China)WZWeiyan ZhengFirst Affiliated Hospital Zhejiang University

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Implication

Clinical analysis reveals prophylactic IT chemotherapy may delay CNSL onset in AML patients, indicating potential strategies for management.

Key Points

  • To analyze clinical characteristics of AML patients developing CNSL and evaluate prophylactic IT chemotherapy effects.
  • Retrospective analysis of 54 AML patients with CNSL at a Bone Marrow Transplantation Center.
  • Assessment of clinical parameters, gene mutations, chromosomal abnormalities, and prophylactic IT strategies.
  • Comparison of CNSL incidence and outcomes between patients receiving prophylactic IT chemotherapy and those who did not.
  • Prophylactic IT chemotherapy delayed CNSL onset, particularly in AML-M5 and AML-M2 subtypes.
  • 14 patients (19.15%) experienced bone marrow and CNSL relapse, and 32 (68.09%) had simple CNSL relapse.
  • No significant difference in overall survival rates between prophylactic and control groups.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da05https://doi.org/10.1182/blood-2025-5184
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central nervous system involvement in pediatric Acute Myeloid Leukemia: A comprehensive report from the AML-BFM group2025
  2. 2Effectiveness of prophylactic intrathecal chemotherapy and risk factors of central nervous system relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia2025 · 1 citations
  3. 3Central nervous system disease status significantly impacts survival in pediatric acute myeloid leukemia: A report from Children's Oncology Group study AAML18312025
  4. 4Intrathecal chemotherapy and central nervous system relapse in acute lymphoblastic leukemia.2026
  5. 5An abnormality in the cerebrospinal fluid before transplantation is predictive of poor outcomes after allotransplantation in AML patients2024