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December 8, 2025Blood

Central nervous system involvement in pediatric Acute Myeloid Leukemia: A comprehensive report from the AML-BFM group

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Authors

KKKatje KleyerEssen University HospitalMSMichael M. SchuendelnEssen University Hospital

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Overview

Retrospective analysis shows CNS involvement and leukocyte count influence patient outcomes in children with AML, suggesting closer monitoring is necessary.

Key Points

  • This research evaluates the impact of CNS involvement on the outcomes of pediatric patients with acute myeloid leukemia.
  • Conducted a retrospective analysis of pediatric AML patients diagnosed between 2012 and 2022
  • Evaluated data from the AML-BFM 2012 and 2017 registries
  • Analyzed overall survival and event-free survival using the Kaplan-Meier method
  • CNS involvement was observed in 8.6% of patients at diagnosis
  • No significant difference in overall survival or event-free survival between CNS positive and negative patients
  • CNS involvement correlated with elevated leukocyte counts and several genetic mutations

Cite This Study

Kleyer et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da61https://doi.org/10.1182/blood-2025-3403
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical analysis of central nervous system leukemia in patients with Acute Myeloid Leukemia2025
  2. 2Central nervous system disease status significantly impacts survival in pediatric acute myeloid leukemia: A report from Children's Oncology Group study AAML18312025
  3. 3Disease characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) involvement2025
  4. 4Treatment Outcomes and Factors Affecting Survival in Pediatric Acute Myeloid Leukemia2026
  5. 5Central nervous system involvement and relapse in adult acute lymphoblastic leukaemia—a population‐based analysis in 2007–20222026