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This research investigates the disease characteristics and outcomes of adult patients with acute lymphoblastic leukemia presenting with CNS involvement.

December 8, 2025BloodOpen Access

Disease characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) involvement

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This research investigates the disease characteristics and outcomes of adult patients with acute lymphoblastic leukemia presenting with CNS involvement.
Retrospective chart review of adult patients with acute lymphoblastic leukemia at Weill Cornell Medical Center from 2012 to 2023.
CNS involvement defined using cytology, flow cytometry and/or imaging data.
Analysis included patient demographics, treatment regimens, and survival outcomes.
50.3% of the cohort were female with a mean age of 50.7 years.
26 patients (13.6%) presented with CNS involvement at diagnosis, with higher baseline WBC and a more likely T cell disease phenotype.
Overall survival was comparable between patients with and without baseline CNS involvement.

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Implication

Retrospective analysis reveals CNS involvement affects outcomes in acute lymphoblastic leukemia patients, suggesting risk factors for diagnosis.

Cite This Study

Canaani et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de63 https://doi.org/10.1182/blood-2025-1557

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Implication

Retrospective analysis reveals CNS involvement affects outcomes in acute lymphoblastic leukemia patients, suggesting risk factors for diagnosis.

Disease characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) involvement

Key Points

Discussion

Implication

Cite This Study

Disease characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults with central nervous system (CNS) involvement

Key Points

Discussion

Implication

Cite This Study

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