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This research examines the prognostic implications of CNS involvement in pediatric T-cell acute lymphoblastic leukemia (T-ALL).

November 16, 2025The OncologistOpen Access

CNS Involvement-positive Disease in Consolidation/Maintenance Stage is a Poor Prognostic Factor in Pediatric T-ALL: A Chinese Single-center Report

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Findings reveal CNS involvement as a poor prognostic factor in pediatric T-ALL, highlighting the need for targeted therapy and immunotherapy.

This research examines the prognostic implications of CNS involvement in pediatric T-cell acute lymphoblastic leukemia (T-ALL).
Retrospective examination of 185 pediatric T-ALL patients from a single center
Analyzed correlations between CNS involvement and survival rates
Evaluated treatment stages: induction, consolidation, and maintenance
CNS involvement during maintenance was linked to lower overall survival rates (46.2% vs 67.5% and 80.7%)
Event-free survival significantly decreased in patients with CNS involvement during consolidation
Higher cumulative recurrence rates observed in those with CNS involvement during maintenance compared to induction stage

Xiaoming et al. (2025) studied this question.

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Findings reveal CNS involvement as a poor prognostic factor in pediatric T-ALL, highlighting the need for targeted therapy and immunotherapy.