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December 8, 2025BloodOpen Access

Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia

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Authors

DLDeyan LiuYLYue LüYZYanli Zhao

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Overview

Retrospective analysis shows improved survival in infants with leukemia influenced by minimal residual disease status.

Key Points

  • To evaluate outcomes of allogeneic hematopoietic stem cell transplantation in infants with leukemia.
  • Retrospective analysis of 126 infants undergoing allo-HSCT at two hospitals.
  • Assessment of overall survival based on pre-transplant remission and minimal residual disease (MRD).
  • Evaluation of the effectiveness of haploidentical versus unrelated donors.
  • Successful engraftment in 100% of patients.
  • 3-year overall survival was 91.1% in CR1 for acute lymphoblastic leukemia.
  • MRD positivity was associated with inferior survival outcomes.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da2dhttps://doi.org/10.1182/blood-2025-6053
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Allogeneic Hematopoietic Stem Cell Transplantation in Infant Leukemia: Vague Prospects? (Series Cases and Brief Review)2025
  2. 2Allogeneic Hematopoietic Stem Cell Transplantation for Infant Leukemia: A Single-Center Case Series and Narrative Review2025
  3. 3Allogeneic hematopoietic stem cell transplantation outcomes in pediatric patients with refractory acute myeloid leukemia2024
  4. 4Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting2024 · 4 citations
  5. 5Excellent Outcomes of Hematopoietic Stem Cell Transplant for Pediatric High Risk and Relapsed Acute Myeloid Leukemia–A Decade Long Experience From Developing Nation2025