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December 8, 2025BloodOpen Access

Allogeneic hematopoietic stem cell transplantation outcomes in pediatric acute lymphoblastic leukemia: A multicenter analysis from the cccg-ALL-2015 protocol

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Authors

XHXiaohang HuangShanghai Children's Medical CenterYZYiping ZhuShanghai Medical College of Fudan UniversityJPJing PanNational Vaccine and Serum Institute

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Overview

Retrospective analysis shows HSCT benefits high-risk pediatric ALL patients, suggesting expanded therapeutic potential.

Key Points

  • To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia.
  • Retrospective analysis of pediatric patients who received allo-HSCT from 2015 to 2019
  • Data collected from 20 hospitals under the CCCG-ALL protocol
  • Survival analyses performed using Kaplan-Meier methodology and Cox proportional hazards modeling.
  • 5-year overall survival (OS) for HSCT patients was 60.8%, with event-free survival (EFS) at 56.1%
  • Transplantation at first complete remission yielded superior OS compared to later remissions
  • Haploidentical HSCT showed reduced relapse rates but increased chronic GVHD incidence.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e430https://doi.org/10.1182/blood-2025-6074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia2025
  2. 2Superior Survival with Allogeneic Hematopoietic Stem Cell Transplantation versus Chemotherapy for High-Risk Adult Acute Lymphoblastic Leukemia in PDT-ALL-2016 Pediatric-Inspired Cohort2024 · 2 citations
  3. 3Outcomes of pediatric patients transplanted for B-ALL with high-risk cytogenetics- a 20-year experience from LMIC setting2025
  4. 4Patterns of relapse and survival outcomes in pediatric ALL from a single center cohort under the CCCG ALL 2015 protocol2026
  5. 5Excellent Survival Following Low‐Intensity Approaches Prior to Allo‐HSCT in Ph+ ALL: A Comprehensive Meta‐Analysis2026