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December 8, 2025Blood

Outcomes of pediatric patients transplanted for B-ALL with high-risk cytogenetics- a 20-year experience from LMIC setting

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Authors

RRRawad Rihani

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Overview

Retrospective review shows survival improvement in pediatric patients with high-risk B-ALL undergoing transplantation, suggesting effective treatment modalities.

Key Points

  • This research aims to assess the transplant outcomes of pediatric patients with high-risk cytogenetic features in B-ALL.
  • Retrospective chart review of pediatric patients transplanted for B-ALL
  • Data extraction from electronic medical records regarding disease characteristics and clinical outcomes
  • Utilization of descriptive statistics and Kaplan-Meier method for survival analysis
  • Eighty-two pediatric patients diagnosed with B-ALL, median age of 4.8 years
  • KMT2A rearrangement was the most common genetic abnormality in 50% of patients
  • Eighteen percent overall mortality rate post-transplant, with most deaths occurring due to disease relapse

Cite This Study

Rawad Rihani (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd0bhttps://doi.org/10.1182/blood-2025-7831
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  4. 4Excellent Outcomes of Hematopoietic Stem Cell Transplant for Pediatric High Risk and Relapsed Acute Myeloid Leukemia–A Decade Long Experience From Developing Nation2025
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