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June 6, 2026Discover OncologyOpen Access

Patterns of relapse and survival outcomes in pediatric ALL from a single center cohort under the CCCG ALL 2015 protocol

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Authors

JFJianming FangHLHongyan LiuQLQi Liu

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Overview

Retrospective study characterizes relapse and post-relapse outcomes in pediatric ALL, indicating critical risk factors for prognosis.

Key Points

  • To analyze relapse patterns, risk factors for relapse, and the prognostic determinants affecting survival outcomes in pediatric ALL patients.
  • Retrospective analysis of 380 children diagnosed with ALL from 2016 to 2019.
  • Evaluation of relapse timing (very early, early, late), sites (bone marrow vs. extramedullary), and early treatment response using morphology and MRD.
  • Post-relapse survival estimated using Kaplan-Meier methods.
  • Relapse rate was 11.1%, with predominantly isolated bone marrow relapses (69%) and very early relapses (47.6%).
  • Relapse varied by risk group: low-risk (5.9%), intermediate-risk (10.4%), and high-risk (22.4%) with significant p-values.
  • Post-relapse survival was significantly affected by timing and risk group, with very early relapses leading to a survival of only 7.2 months.

Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/6a23bbbb71a5da9775e772c1https://doi.org/10.1007/s12672-026-05358-6
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