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December 8, 2025BloodOpen Access

Bone marrow CD57+ LGL cells comprised of NK and CD8 T cells drive bone marrow failure in Myelodysplastic Syndromes

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Authors

CSColin J. R. SheppardAustralian College of Optometry

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Implication

Findings show expanded NK cells and CD8 T cells linked to bone marrow failure in myelodysplastic syndromes, indicating IVIG may aid treatment.

Key Points

  • The study aims to investigate the role of CD57+ LGL cells in bone marrow failure in myelodysplastic syndromes (MDS).
  • Analyzed bone marrow and blood samples from 279 MDS patients using clinical flow cytometry
  • Conducted scRNA-seq and TCR-seq on bone marrow mononuclear cells from patients
  • Performed mass cytometry for profiling immune subsets in 19 MDS patients
  • Executed in vitro killing assays with BM-derived LGLs
  • Retrospective analysis of MDS patients treated with IVIG for autoimmune cytopenias
  • Strong association between expanded BM NK cells and bone marrow failure, with NK-LGL or CD8-LGLs over 20% of lymphocytes
  • High abundance of CD57+CD8 T cells and NK cells in MDS patients
  • CD8 T cells from MDS patients have higher activation and expression levels of perforin and granzymes
  • IVIG treatment showed a 73% overall response rate among MDS patients with LGL expansion

Cite This Study

Colin J. R. Sheppard (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da31https://doi.org/10.1182/blood-2025-5619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of CD8 cytotoxic t-cells in patients with myelodysplastic syndrome (MDS) and T-cell large granulocyte lymphocytic leukemia (T-LGLL) reveal a distinct phenotype compared to those with t-lgll2025
  2. 2Bone marrow immune and stromal niche remodeling in myelodysplastic neoplasm patients under erythropoietic therapies by 29-color full-spectrum flow cytometry2025
  3. 3Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis2025
  4. 4Immune restoration in long-term myeloma survival revealed by single-cell RNA-sequencing2025
  5. 5In depth characterization of autologous infused bhv-1100 armored memory-like NK cells in MRD+ multiple myeloma patients receiving autologous stem cell transplant2025