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December 8, 2025Blood

Analysis of CD8 cytotoxic t-cells in patients with myelodysplastic syndrome (MDS) and T-cell large granulocyte lymphocytic leukemia (T-LGLL) reveal a distinct phenotype compared to those with t-lgll

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Authors

RPRosana Moreira PereiraUniversity of Colorado Anschutz Medical CampusKGKellen GilUniversity of Colorado Anschutz Medical CampusWSWilliam ShowersUniversity of Colorado Anschutz Medical Campus

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Implication

Observational analysis suggests MDS/T-LGLL patients show increased neutropenia and altered T-cell exhaustion markers.

Key Points

  • To investigate the unique immunobiological characteristics of patients presenting with MDS/T-LGLL overlap.
  • Retrospective analysis of patients with MDS and T-LGLL overlap
  • Single-cell RNA and T-cell receptor sequencing on bone marrow samples
  • Bulk RNA sequencing on T-LGLL cells
  • Evaluation of plasma cytokine levels using ELISA
  • MDS/T-LGLL patients exhibited higher rates of neutropenia (average ANC 0.72 cells/uL)
  • Lower frequency of STAT3/5 mutations in MDS/T-LGLL patients (12.5% vs 43%)
  • Increased infection-related deaths in MDS/T-LGLL patients (57% vs 0%)
  • Distinct T-cell exhaustion markers higher in MDS/T-LGLL compared to T-LGLL alone

Cite This Study

Pereira et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236df87https://doi.org/10.1182/blood-2025-5610
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis2025
  2. 2Bone marrow CD57+ LGL cells comprised of NK and CD8 T cells drive bone marrow failure in Myelodysplastic Syndromes2025
  3. 3Tracing the evolution of clonal T cell responses in LGL leukemia with single-cell whole genome sequencing2025
  4. 4Multilineage lymphoid clonal hematopoiesis: a cross-sectional, correlative analysis of plasma cell dyscrasias and large granular lymphocytic leukemia2026
  5. 5Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025