Observational data shows first-line treatment varies by frailty and comorbidity burden in transplant-ineligible multiple myeloma patients.
Key Points
To characterize first-line treatment patterns in transplant-ineligible patients with newly diagnosed multiple myeloma based on age, frailty, and comorbidity.
Identified transplant-ineligible NDMM patients using US health insurance claims databases (Optum, HealthVerity)
Categorized patients based on frailty and comorbidity indices
Calculated standardized mean differences to analyze treatment regimen patterns
Identified 14,933 transplant-ineligible NDMM patients across two databases
Most common regimens included VRd, Vd, and Rd
Patients with higher frailty more likely to receive doublets over triplets and quadruplets.