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December 8, 2025Blood

Intensive chemotherapy bridging to allogeneic hematopoietic cell transplant in relapsed or refractory Acute Myeloid Leukemia

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Authors

PKPaul KollerDYDongyun YangIAIbrahim Aldoss

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Overview

Retrospective analysis reveals intensive chemotherapy followed by transplant improves outcomes in R/R AML, indicating safety of this approach.

Key Points

  • This research aims to assess the feasibility and outcomes of intensive chemotherapy followed by allogeneic hematopoietic cell transplant in patients with relapsed or refractory acute myeloid leukemia.
  • Retrospective analysis of adult patients with R/R AML treated at City of Hope.
  • Included patients underwent intensive chemotherapy prior to HCT within 60 days.
  • Endpoints measured included overall survival, progression-free survival, cumulative incidence of relapse, and non-relapse mortality.
  • 63.3% of patients achieved complete remission/CR without hematological recovery before HCT.
  • Median overall survival and progression-free survival from HCT were 12.7 months and 8.1 months, respectively.
  • Cumulative incidence of relapse at 12 months was 34.4% with a non-relapse mortality rate of 20.6%.

Cite This Study

Koller et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da66https://doi.org/10.1182/blood-2025-3411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-Intensity Pretransplant Therapy in Acute Myeloid Leukemia: A 13-Year Single-Center Experience2025
  2. 2Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025
  3. 3Results of treating relapsed and refractory acute myeloid leukemia at a reference center in Latin America: the importance of outpatient hematopoietic stem cell transplantation2024 · 1 citations
  4. 4Cladribine, cytarabine, and venetoclax-based regimens are associated with durable remissions in patients (pts) with newly diagnosed Acute Myeloid Leukemia undergoing allogeneic stem cell transplantation2025
  5. 5Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.2026