What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 2, Pre-Registered Trial).

What question did this study set out to answer?

To evaluate the safety and efficacy of total marrow and lymphoid irradiation with cyclophosphamide and etoposide prior to hematopoietic cell transplantation in relapsed/refractory leukemia patients.

December 8, 2025BloodOpen Access

Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality

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Authors

JPJoycelynne PalmerCity of Hope YWYan WangShanxi Jincheng Anthracite Mining Group (China)BBBrian BallBrigham and Women's Hospital

Discussion

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Implication

Single-arm phase 2 trial shows low non-relapse mortality and improved survival in relapsed leukemia patients after TMLI and chemotherapy.

Key Points

To evaluate the safety and efficacy of total marrow and lymphoid irradiation with cyclophosphamide and etoposide prior to hematopoietic cell transplantation in relapsed/refractory leukemia patients.
Single-arm phase 2 trial in 104 patients with relapsed/refractory leukemia.
TMLI (2000 cGy) combined with cyclophosphamide and etoposide as a conditioning regimen.
Graft versus host disease prophylaxis included tacrolimus and sirolimus.
99% of patients achieved neutrophil recovery by a median of 15 days.
96% of patients reached a complete remission after transplantation.
The cumulative incidence of relapse/progression at 2 years was 51% and non-relapse mortality was 14%.

Cite This Study

Palmer et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3e4 https://doi.org/10.1182/blood-2025-2441

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Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality

Discussion

Member takes

Implication

Key Points

Cite This Study

Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality

Discussion

Member takes

Implication

Key Points

Cite This Study

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