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December 8, 2025BloodOpen Access

Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia

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Authors

MCMiguel CamposLTLuz TarinALAndrés Gómez‐De León

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Overview

Phase 2 trial reveals outpatient transplantation safety in acute lymphoblastic leukemia, suggesting feasible TMLI conditioning.

Key Points

  • To evaluate the safety and feasibility of total marrow and lymphoid irradiation in outpatient allogeneic transplantation for acute lymphoblastic leukemia.
  • Phase 2 trial conducted at a single center
  • Included patients aged 16-45 with relapsed or refractory acute lymphoblastic leukemia
  • Conditioning regimen included cyclophosphamide and fludarabine followed by TMLI
  • Graft-versus-host disease prophylaxis involved tacrolimus or cyclosporin A and mycophenolate mofetil
  • Patients monitored on an outpatient basis post-transplant until engraftment
  • TMLI was feasible with 57% of patients fully outpatient
  • Median age of participants was 20 years; 14 patients enrolled
  • Incidence of acute graft-versus-host disease was 57.1%
  • One-year overall survival was 81.3%
  • No early deaths within 60 days post-transplant

Cite This Study

Campos et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dbbahttps://doi.org/10.1182/blood-2025-6000
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting2025
  2. 2Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025
  3. 3Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with Relapsed/Refractory (R/R) disease2025
  4. 4Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis2025
  5. 5Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study2026