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April 19, 2026Cell TransplantationOpen Access

Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study

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Authors

YZY C ZhangRZRan ZhangXCXiena Cao

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Overview

Multicenter study evaluates feasibility and safety of total marrow irradiation in allogeneic hematopoietic stem cell transplantation, suggesting positive outcomes.

Key Points

  • This study aimed to assess the real-world efficacy and safety of total marrow irradiation as conditioning prior to allogeneic hematopoietic stem cell transplantation.
  • Retrospective inclusion of patients undergoing allo-HSCT with TMI-based conditioning.
  • Conducted across four Chinese centers from 2017 to 2024.
  • Analysis of endpoints including overall survival, disease-free survival, and nonrelapse mortality.
  • Among 205 patients, 2-year overall survival was 71.7% and disease-free survival was 60.0%.
  • One-year cumulative incidences of relapse and nonrelapse mortality were 20.2% and 13.8%, respectively.
  • Day-100 grade II-IV acute graft-versus-host disease occurred in 32.9% of patients.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69e471ef010ef96374d8e2eahttps://doi.org/10.1177/09636897261440297
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis2025
  2. 2Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source2026
  3. 3Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia2025
  4. 4Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting2025
  5. 5Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025