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December 8, 2025BloodOpen Access

Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis

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Authors

LWLing Wang

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Overview

Retrospective analysis shows TMI conditioning reduces toxicity and improves outcomes in elderly with hematological malignancies, suggesting a safer treatment option.

Key Points

  • This research aims to evaluate the safety and efficacy of total marrow irradiation-based conditioning in elderly or frail patients undergoing stem cell transplantation.
  • Conducted a retrospective analysis of patients aged ≥ 60 or with poor performance status who received TMI-based conditioning.
  • Patients received 12Gy TMI in three consecutive days and were supplemented with fludarabine and thiotepa.
  • Graft-versus-host disease prophylaxis utilized post-transplant cyclophosphamide.
  • All patients achieved engraftment with a median recovery of neutrophils in 14 days and platelets in 16 days.
  • 1-year overall survival was 79.2% and disease-free survival was 81.6%.
  • The 1-year incidence of moderate/severe chronic GVHD was 31.5%.

Cite This Study

Ling Wang (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1d6https://doi.org/10.1182/blood-2025-2444
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study2026
  2. 2Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study2025
  3. 3Total marrow irradiation-based, reduced-intensity conditioning regimen for elderly patients undergoing hematopoietic cell transplantation for hematological malignancies2026
  4. 4Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source2026
  5. 5Safety of myeloablative total marrow and lymphoid irradiation versus chemotherapy-based conditioning in adults with high-risk acute lymphoblastic leukemia in a limited resources setting2025