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December 8, 2025Blood

Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study

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Authors

LKLucila Nassif KerbauyHospital Israelita Albert EinsteinCMCarolina MarquesUniversity of Trás-os-Montes and Alto DouroJNJade Zezzi Martins do NascimentoHospital Israelita Albert Einstein

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Implication

Prospective analysis shows total marrow irradiation improves progression-free survival in elderly hematopoietic cell transplantation patients.

Key Points

  • To evaluate the efficacy and safety of a total marrow irradiation-based reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 or older.
  • Prospective study of patients aged 60 years or older receiving HCT with a RIC regimen including busulfan, fludarabine, and total marrow irradiation.
  • Patients received chemotherapy and immunosuppression regimens post-transplant, with variations according to donor match status.
  • Median age of participants was 67 years, with 50% having refractory or active disease prior to transplant.
  • Neutrophil engraftment achieved in 93% of patients, median engraftment time was 17 days.
  • The 24-month progression-free survival rate was 45%, and overall survival rate was 45%, indicating promising outcomes in a challenging population.

Cite This Study

Kerbauy et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3e3https://doi.org/10.1182/blood-2025-2439
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide: A prospective study2025
  2. 2Total marrow irradiation-based, reduced-intensity conditioning regimen for elderly patients undergoing hematopoietic cell transplantation for hematological malignancies2026
  3. 3Total marrow irradiation based conditioning for allogeneic hematopoietic stem cell transplantation in elderly or frail patients with hematological malignancies: A single center analysis2025
  4. 4Conditioning intensity in myelodysplastic patients aged ≥ 50 years undergoing allogeneic hematopoietic cell transplantation (allo-HCT): a study on behalf of the chronic malignancies working party of the EBMT2025 · 2 citations
  5. 5A Baltimore-modified non-TBI conditioning for allogeneic stem cell transplantation in elderly or unfit patients with haploidentical or mismatched donors2026