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August 13, 2026Clinical & Translational OncologyOpen Access

Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source

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Authors

UVU. Corro VerdeJFJesús Romero FernándezBHBeatriz Gil Haro

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Overview

Retrospective trial assessing survival and toxicity in allogeneic hematopoietic stem-cell transplant recipients, indicating the importance of stem cell source.

Key Points

  • This study aimed to evaluate survival outcomes and treatment-related toxicity in patients receiving total body irradiation-based conditioning before allogeneic transplantation.
  • Conducted a retrospective single-center study from 2011 to 2020
  • Included 58 patients who underwent allo-HSCT with TBI-based conditioning and assessed various outcomes
  • Analyzed primary endpoints: overall survival, disease-free survival, and relapse; secondary endpoints included non-relapse mortality, disease-related mortality, and toxicity.
  • At 12 months, overall survival was 64%, disease-free survival was 48%, and relapse was 29%.
  • PBSC transplantation resulted in significantly higher overall survival at 12 months compared to UCB (78% vs. 37%, p < 0.001).
  • Non-relapse mortality rates were notably lower in PBSC recipients compared to UCB (5% vs. 43%, p < 0.001).

Cite This Study

Verde et al. (2026) studied this question.

synapsesocial.com/papers/6a7d768a2b0e0cff3f63ff9ahttps://doi.org/10.1007/s12094-026-04523-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study2026
  2. 2Impact of Total Body Irradiation Dose in Reduced-Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia.2026
  3. 3Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  4. 4Reduced intensity conditioning with 8 Gy total body irradiation in adult patients with acute lymphoblastic leukemia2025 · 3 citations
  5. 5Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen2025 · 1 citations