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December 6, 2025Bone Marrow TransplantationOpen Access

Reduced intensity conditioning with 8 Gy total body irradiation in adult patients with acute lymphoblastic leukemia

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Authors

KWKlaus WethmarMEMatthias EdingerKSKerstin Schäfer-Eckart

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Overview

Retrospective analysis shows 64% survival rates in adults with acute lymphoblastic leukemia after reduced intensity conditioning, suggesting feasible treatment pathways.

Key Points

  • Survival rates at three years reached 64% for disease-free survival in high-risk adult acute lymphoblastic leukemia patients.
  • Patients had a median age of 52 years, with 93% maintaining a good performance status (ECOG 0/1).
  • Analysis of registry data from the German Multicenter Study Group for Adult ALL revealed outcomes with 8 Gy total body irradiation.
  • These findings imply that 8 Gy total body irradiation is a feasible conditioning option similar to previous higher dose regimens.

Cite This Study

Wethmar et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb4bfhttps://doi.org/10.1038/s41409-025-02762-4
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