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September 10, 2025Leukemia & lymphoma/Leukemia and lymphoma

Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen

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Authors

DADelaram AmiriTehran University of Medical SciencesMMMandana MirzaeiTehran University of Medical SciencesTBTanaz BahriShariati Hospital

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Implication

Retrospective analysis reveals improved overall survival and disease-free survival in adult ALL patients after TBI-free transplantation, indicating its potential as a viable alternative.

Key Points

  • Overall survival significantly improved from 38.3% to 48.1% in patients post-2010.
  • Disease-free survival also increased from 36.6% to 42.0% in the same time frame.
  • Relapse incidence decreased notably from 47.5% to 40.8% post-2010.
  • Non-relapse mortality remained stable during the period at around 28.5% to 24.9%.

Cite This Study

Amiri et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce7054b1d3bfb60f5a59https://doi.org/10.1080/10428194.2025.2548968
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Efficacy of allogeneic hematopoietic stem cell transplantation based on a total body irradiation conditioning treatment regimen for adult acute lymphocytic leukemia].2024 · 1 citations
  2. 2Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia2017 · 98 citations