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July 26, 2026Annals of HematologyOpen Access

Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study

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Authors

MLMinglu LiAerospace Center HospitalSZShuqin ZhangEast China University of Science and TechnologyXMXiaoyong ManAerospace Center Hospital

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Implication

Retrospective study evaluates thiotepa's effect on outcomes in R/R leukemia during transplant conditioning, suggesting lower relapse risk.

Key Points

  • The study aims to evaluate the impact of adding thiotepa to TBI-based conditioning on survival and relapse rates in patients with relapsed/refractory acute leukemia and lymphoma.
  • Single-center retrospective analysis from 2020 to 2025
  • Included patients were matched by propensity score (1:2) based on 9 covariates
  • Primary endpoints assessed were overall survival and disease-free survival using Kaplan-Meier and Fine-Gray methods.
  • Overall survival was comparable: HR = 0.901, 95% CI 0.569–1.425, P = 0.655
  • Disease-free survival was comparable: HR = 0.809, 95% CI 0.504–1.299, P = 0.380
  • 1-year relapse incidence was lower with TBI + TT: 6.7% vs. 17.8%, Gray’s P = 0.035, multivariable sHR = 0.280, 95% CI 0.083–0.942, P = 0.040.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78d27https://doi.org/10.1007/s00277-026-07198-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation2025
  2. 2Efficacy of thiotepa-containing conditioning regimens and mucositis burden in allogeneic HSCT for relapsed/refractory acute leukemia with extramedullary disease2025
  3. 3Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source2026
  4. 4Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025
  5. 5Impact of Total Body Irradiation Dose in Reduced‐Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia2026