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December 8, 2025BloodOpen Access

Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation

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Authors

RCRui CuiQMQiaoling MaJWJialin Wei

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Overview

Retrospective study shows TBC regimen improved disease-free survival in patients with R/R haematologic malignancies, indicating potential benefits for allogeneic transplantation.

Key Points

  • To evaluate the efficacy and safety of the thiotepa, busulfan, and cyclophosphamide conditioning regimen in patients with relapsed/refractory haematologic diseases.
  • Retrospective study of 27 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) with TBC regimen.
  • Regimen consisted of thiotepa, busulfan, and cyclophosphamide administered over 2 days.
  • Monitored for overall survival, disease-free survival, and incidence of relapse.
  • 85.2% overall survival at 1 year and 76.5% at 2 years.
  • 81.5% disease-free survival at 1 year and 62.8% at 2 years.
  • Cumulative incidence of relapse was 14.8% at 1 year and 31.0% at 2 years.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db95https://doi.org/10.1182/blood-2025-5974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  2. 2Improved survival for myeloid malignancy patients receiving thiotepa/cyclophosphamide (TT/Cy) versus total body irradiation/cyclophosphamide (TBI/Cy) conditioning and allogeneic stem cell transplantation.2024
  3. 3Efficacy of thiotepa-containing conditioning regimens and mucositis burden in allogeneic HSCT for relapsed/refractory acute leukemia with extramedullary disease2025
  4. 4Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party2025
  5. 5Mitoxantrone hydrochloride liposome injection combined with thiotepa-busulfan-fludarabine (MTBF) as conditioning regimen in patients undergoing allogeneic hematopoietic stem cell transplantation for central nervous system leukemia:a single-center retrospective case-control study2025