Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Mitoxantrone hydrochloride liposome injection combined with thiotepa-busulfan-fludarabine (MTBF) as conditioning regimen in patients undergoing allogeneic hematopoietic stem cell transplantation for central nervous system leukemia:a single-center retrospective case-control study

View Full Paper
Ask AI
Bookmark
Share

Authors

YWYuqi WangSichuan University

Discussion

Loading...

Member takes

Implication

Case-control study compares safety and efficacy of MTBF and TBF in CNS leukemia patients undergoing allo-HSCT, suggesting MTBF may offer better outcomes.

Key Points

  • This study aims to compare the safety and efficacy of MTBF and TBF as conditioning regimens for CNS leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.
  • Single-center retrospective case-control study
  • 21 patients with acute leukemia and CNS leukemia were analyzed
  • Data compared between MTBF (n=7) and TBF (n=14) groups regarding adverse effects and survival rates.
  • Median age of patients was 26 years, with successful hematopoietic recovery in all
  • One-year progression free survival was 69.3% and overall survival was 72.1%
  • No relapses in the MTBF group; six relapses in the TBF group.

Cite This Study

Yuqi Wang (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3d1https://doi.org/10.1182/blood-2025-2423
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation2025
  2. 2Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source2026
  3. 3Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party2025
  4. 4Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  5. 5Total body irradiation versus chemotherapy before stem cell transplantation in children aged two to four with acute lymphoblastic leukemia—an EBMT pediatric diseases working party study2026