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December 8, 2025BloodOpen Access

Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party

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Authors

AFAllain-Thibeault FerhatSBStéfania BramantiJSJaime Sanz

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Overview

Retrospective analysis shows thiotepa dose influences graft versus host disease and relapse risk in AML transplantation.

Key Points

  • To evaluate the impact of thiotepa dosage on outcomes in haploidentical stem cell transplantation for acute myeloid leukemia.
  • Retrospective analysis of haplo-HSCT from EBMT registry data (2010-2022)
  • Comparison of TBF conditioning with varying thiotepa doses in AML patients
  • Assessment of patient outcomes including overall survival, relapse incidence, and graft versus host disease.
  • 2393 AML patients analyzed, 65.7% 2-year overall survival
  • High-dose thiotepa associated with increased risk of severe graft versus host disease
  • No benefit observed in relapse incidence with high-dose thiotepa compared to lower doses.

Cite This Study

Ferhat et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db44https://doi.org/10.1182/blood-2025-5980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A single-centre comparison of thiotepa-treosulfan versus thiotepa-busulfan based conditioning regimens in adults with haematological malignancies undergoing allogeneic haematopoietic stem cell transplant.2025
  2. 2Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation2025
  3. 3Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  4. 4Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  5. 5GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial2026 · 2 citations