What question did this study set out to answer?

This study aims to evaluate the effectiveness of the Treo/Flu regimen compared to TBF in reducing non-relapse mortality during allogeneic transplantation in lymphoma patients.

February 14, 2026British Journal of HaematologyOpen Access

Treosulfan/fludarabine versus thiotepa/busulfan/fludarabine for allogeneic haematopoietic cell transplantation in lymphoma in the post‐transplant cyclophosphamide era: A GETH ‐ TC study

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Authors

MPMarta Bravo PeñaInstitut Català d'Oncologia LLLorenzo LazzariVita-Salute San Raffaele University DMDebbie MartinezInstitut Català d'Oncologia

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Implication

Retrospective study compares conditioning regimens for transplantation in lymphoma, indicating Treo/Flu may reduce non-relapse mortality.

Key Points

This study aims to evaluate the effectiveness of the Treo/Flu regimen compared to TBF in reducing non-relapse mortality during allogeneic transplantation in lymphoma patients.
Conducted as a retrospective, international multicentre study
Included 178 adults with lymphoid malignancies receiving alloHCT with PTCy
Compared conditioning regimens Treo/Flu and TBF
Primary endpoint focused on non-relapse mortality
Performed multivariate analysis to assess outcomes
Three-year non-relapse mortality was significantly lower for Treo/Flu at 14.0% compared to 33.0% for TBF
Multivariate analysis showed Treo/Flu had a hazard ratio of 0.44 for lower 3-year non-relapse mortality
Moderate to severe chronic graft-versus-host disease was higher with Treo/Flu at 26.0% versus 9.9% for TBF
Graft-versus-host disease-free and relapse-free survival was comparable between regimens

Cite This Study

Peña et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe56f91 https://doi.org/10.1111/bjh.70367

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Treosulfan/fludarabine versus thiotepa/busulfan/fludarabine for allogeneic haematopoietic cell transplantation in lymphoma in the post‐transplant cyclophosphamide era: A GETH ‐ TC study

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Key Points

Cite This Study

Treosulfan/fludarabine versus thiotepa/busulfan/fludarabine for allogeneic haematopoietic cell transplantation in lymphoma in the post‐transplant cyclophosphamide era: A GETH ‐ TC study

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Cite This Study

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