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December 8, 2025BloodOpen Access

A single-centre comparison of thiotepa-treosulfan versus thiotepa-busulfan based conditioning regimens in adults with haematological malignancies undergoing allogeneic haematopoietic stem cell transplant.

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Authors

YCYunxin ChenFLFrancesca LimYLYeh Ching Linn

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Overview

Retrospective analysis shows similar survival and safety outcomes in patients undergoing stem cell transplant with thiotepa-treosulfan versus thiotepa-busulfan, indicating equivalence in severe events

Key Points

  • This analysis investigates outcomes of thiotepa-treosulfan compared to thiotepa-busulfan in haematological malignancies.
  • Retrospective analysis of adult patients undergoing allogeneic HSCT.
  • Comparison of outcomes for thiotepa-treosulfan and thiotepa-busulfan-based regimens.
  • Survival and event rates evaluated using statistical models.
  • 1-year overall survival was similar between both conditioning regimens.
  • Incidence of acute graft versus host disease and 100-day non-relapse mortality were comparable.
  • No significant differences in adverse events such as infections and mucositis were observed.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db55https://doi.org/10.1182/blood-2025-5982
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treosulfan-based vs. busulfan-based conditioning for hematopoietic stem cell transplantation: A systematic review and meta-analysis.2025
  2. 2“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”2025
  3. 3GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial2026 · 1 citations
  4. 4Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party2025
  5. 5Treosulfan is a safe and effective alternative to busulfan for conditioning in adult allogeneic <scp>HSCT</scp> patients: Data from a single center2024 · 2 citations