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December 8, 2025Blood

Treosulfan-based vs. busulfan-based conditioning for hematopoietic stem cell transplantation: A systematic review and meta-analysis.

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Authors

MBMahnoor BalochFNFnu NamalAAAli Imran Amjad

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Overview

Meta-analysis shows Treosulfan may improve overall survival and reduce GVHD in stem cell transplant patients, suggesting its potential as a safer conditioning agent.

Key Points

  • This review aims to compare the safety and efficacy of Treosulfan-based and Busulfan-based conditioning in hematopoietic stem cell transplantation.
  • Included randomized controlled trials comparing conditioning regimens in stem cell transplantation.
  • Conducted comprehensive searches across multiple databases to identify relevant studies.
  • Performed pooled analysis using risk ratios and mean differences for various outcomes.
  • Treosulfan showed better overall survival, with a risk ratio of 0.73.
  • Lower graft-versus-host disease incidence in Treosulfan group (RR = 0.74).
  • Similar toxicity and treatment-related mortality between both regimens.

Cite This Study

Baloch et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db9chttps://doi.org/10.1182/blood-2025-5997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”2025
  2. 2Treosulfan is a safe and effective alternative to busulfan for conditioning in adult allogeneic <scp>HSCT</scp> patients: Data from a single center2024 · 2 citations
  3. 3A single-centre comparison of thiotepa-treosulfan versus thiotepa-busulfan based conditioning regimens in adults with haematological malignancies undergoing allogeneic haematopoietic stem cell transplant.2025
  4. 4Treosulfan-Based Conditioning in Allogeneic Stem Cell Transplantation for Myelofibrosis: A Systematic Review2026
  5. 5GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial2026 · 1 citations