What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This research evaluates the efficacy and safety of treosulfan compared to busulfan in hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia.

December 8, 2025Blood

“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”

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Authors

FSFNU SawairaLiaquat University of Medical & Health Sciences SVSai Sushrutha Mudupula VemulaSparrow Health System MYMuhammad YasirBacha Khan University

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Implication

Meta-analysis shows treosulfan improves overall response and reduces non-relapse mortality in hematopoietic stem cell transplantation for MDS and AML, pointing to its potential as a safer alternative.

Key Points

This research evaluates the efficacy and safety of treosulfan compared to busulfan in hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia.
Conducted a meta-analysis of 12 studies comprising 7649 adult patients undergoing HSCT for MDS or AML.
Included 3 randomized controlled trials and 9 cohort studies.
Primary outcomes examined were overall response rate, non-relapse mortality, and acute graft-versus-host disease.
Treosulfan-based conditioning resulted in a 24% increase in overall response rate compared to busulfan.
Treosulfan significantly reduced non-relapse mortality, with a relative risk of 0.65.
A trend towards reduced grade III–IV acute graft-versus-host disease was observed, although not statistically significant.

Cite This Study

Sawaira et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3a1 https://doi.org/10.1182/blood-2025-6991

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“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”

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Key Points

Cite This Study

“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”

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Key Points

Cite This Study

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