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December 8, 2025Blood

Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.

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Authors

MAMahmoud AljurfRLRégis Peffault de LatourIBIgor Wolfgang Blau

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Overview

Retrospective analysis shows survival benefits in adolescents and young adults with AML using specific conditioning regimens, highlighting GvHD implications.

Key Points

  • This analysis aims to compare the outcomes of different conditioning regimens for AML patients undergoing HCT.
  • Retrospective analysis of AML patients aged 18-40 in complete remission receiving HCT from 2010 to 2022.
  • Comparison of myeloablative regimens including high-dose TBI, TBF, Bu-Flu, and Bu-Cy.
  • Inclusion of patients from both HLA-matched related and unrelated donors.
  • Bu-Flu and TBF regimens showed better overall survival compared to TBI-based regimens.
  • Two-year overall survival rates were 69.3% for TBI, 81.2% for TBF, and 74.4% for Bu-Flu.
  • Patients receiving Bu-Flu had less Graft-versus-host disease, indicating lower morbidity.

Cite This Study

Aljurf et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cffehttps://doi.org/10.1182/blood-2025-112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total Body Irradiation, Busulfan, Fludarabine Conditioning for Pediatric Acute Myeloid Leukemia Patients Treated with Hematopoietic Stem Cell Transplantation in Second Complete Remission2026
  2. 2An evolving landscape – how changing conditioning regimes can improve myelofibrosis transplant outcomes.2025
  3. 3Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.2026
  4. 4Impact of thiotepa dose in haploidentical allogeneic stem cell transplantation with thiotepa-busulfan-fludarabine conditioning for Acute Myeloid Leukemia in remission: A retrospective analysis of the EBMT acute leukemia working party2025
  5. 5Total body irradiation versus chemotherapy before stem cell transplantation in children aged two to four with acute lymphoblastic leukemia—an EBMT pediatric diseases working party study2026