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May 22, 2026Cancer Research and TreatmentOpen Access

Total Body Irradiation, Busulfan, Fludarabine Conditioning for Pediatric Acute Myeloid Leukemia Patients Treated with Hematopoietic Stem Cell Transplantation in Second Complete Remission

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Authors

JLJae Wook LeeSeoul St. Mary's HospitalSJSuejung JoSeoul St. Mary's HospitalJYJae Won YooSeoul St. Mary's Hospital

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Implication

Randomized trial evaluates conditioning regimens for outcomes in pediatric AML patients post-transplant, suggesting TBI/Bu/Flu improves survival rates.

Key Points

  • This study aims to determine the optimal conditioning regimen for pediatric AML patients undergoing HSCT in second complete remission.
  • Evaluated 43 pediatric AML patients who underwent myeloablative HSCT from 2009 to 2023.
  • Compared outcomes of patients receiving TBI/Bu/Flu versus Bu/Flu conditioning regimens.
  • Reported event-free survival and overall survival at 5-year follow-up.
  • Estimated 5-year event-free survival (EFS) was 57.5%, with TBI/Bu/Flu group showing 73.0% EFS versus 23.1% for Bu/Flu (p=0.004).
  • 5-year overall survival (OS) was 66.8%, all surviving patients remained disease-free at last follow-up.
  • No significant difference in EFS between haploidentical family donor and other donor transplants.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778cd8ahttps://doi.org/10.4143/crt.2026.0086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  2. 2Optimal conditioning intensity: favorable outcome of a 3-day busulfan based regimen in younger acute myeloid leukemia patients2025
  3. 3A phase II multicenter prospective study to evaluate the safety and efficacy of myeloablative-dose treosulfan plus fludarabine (FT14) conditioning regimen in allogeneic hematopoietic stem cell transplantation for AML patients aged 40–65 in first complete remission2026
  4. 4Age- and comorbidity-adjusted busulfan, fludarabine, cytarabine, and low-dose TBI-based conditioning regimen is effective for myelodysplastic syndromes with excess blasts undergoing allogeneic peripheral blood stem cell transplantation2025 · 3 citations
  5. 5Comparable outcomes for TBI-based versus treosulfan based conditioning prior to allogeneic hematopoietic stem cell transplantation in AML and MDS patients2024 · 5 citations