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October 12, 2025Leukemia & lymphoma/Leukemia and lymphoma

Optimal conditioning intensity: favorable outcome of a 3-day busulfan based regimen in younger acute myeloid leukemia patients

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Authors

HPHyun-kyung ParkUlsan CollegeJLJe‐Hwan LeeUlsan CollegeJLJung‐Hee LeeUlsan College

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Implication

Retrospective analysis highlights a 3-day busulfan regimen improving overall survival in younger AML patients, indicating it as the optimal choice.

Key Points

  • A 3-day busulfan regimen resulted in better overall survival rates among younger AML patients undergoing HCT, indicating its efficacy.
  • Overall survival improved significantly with Bu3 compared to 2-day and 4-day regimens, with a p-value of less than 0.001.
  • Multivariate analysis confirmed the OS benefit of Bu3 with a hazard ratio of 0.513, reinforcing its role as the preferred conditioning regimen.
  • Despite lower relapse rates with Bu4, event-free survival was akin to Bu3, suggesting no added advantage in more intensive regimens.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68eb8fe250220ac955d94c4ehttps://doi.org/10.1080/10428194.2025.2560086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluate the Efficacy of Myeloablative Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia at BTH, Vietnam2024
  2. 2Total Body Irradiation, Busulfan, Fludarabine Conditioning for Pediatric Acute Myeloid Leukemia Patients Treated with Hematopoietic Stem Cell Transplantation in Second Complete Remission2026
  3. 3Once-Daily Versus Four-Times-Daily Intravenous Busulfan with Therapeutic Drug Monitoring as Conditioning for Hematopoietic Cell Transplantation in Children2025 · 2 citations
  4. 4Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.2025 · 1 citations
  5. 5Efficacy and safety of Busulfan–Fludarabine versus Busulfan–Cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplant in hematologic malignancy patients: a meta-analysis of randomized controlled trials and observational studies2026