What question did this study set out to answer?

To examine how frailty affects disease outcomes in multiple myeloma patients using UK health data.

December 8, 2025BloodOpen Access

The impact of frailty on real world outcomes for multiple myeloma patients in England – a cohort study from the uncover study group and ukmra frailty group.

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Cohort study reports increased mortality in frail multiple myeloma patients, highlighting the role of frailty and socioeconomic factors.

To examine how frailty affects disease outcomes in multiple myeloma patients using UK health data.
Utilized National Cancer Registration Dataset (NCRD) for patient data from 2014-2021
Heart-related survival and incidence rates evaluated with Poisson regression and Cox models
Assessed comorbidities using Charlson co-morbidity index and adjusted models for demographics
39,521 multiple myeloma patients identified; 40.1% classified as frail
Frail patients had a median overall survival of 31 months compared to 78 months for non-frail
Higher all-cause mortality observed in frail patients with HR of 1.75 as compared to non-frail

Karpha et al. (2025) studied this question.

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