Prospective study shows IRd maintenance enhances progression-free survival and safety in transplant-ineligible NDMM, suggesting better quality of life.
Key Points
To evaluate the efficacy and tolerability of transitioning to IRd maintenance after DRd induction in transplant-ineligible NDMM patients.
Prospective multicenter study enrolling 60 transplant-ineligible NDMM patients.
Patients switched to IRd maintenance after achieving ≥minimal response to DRd induction.
Primary endpoint was 2-year progression-free survival (PFS).
94% of evaluable patients remained progression-free post-transition to IRd.
CR/sCR rate increased from 47.5% to 60.4% (p=0.03).
Safety profile included Grade ≥3 neutropenia (8%) and infections (20% grade 3).