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December 8, 2025BloodOpen Access

Biomarkers of ineffective erythropoiesis in patients with sickle cell anemia, at baseline and while treated with hydroxyurea, in comparison to patients with other iron-loading red cell disorders

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Authors

RWRussell E. WareCincinnati Children's Hospital Medical Center

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Implication

Analysis shows hydroxyurea improves iron overload by decreasing ineffective erythropoiesis in sickle cell anemia patients.

Key Points

  • This research aims to evaluate biomarkers of ineffective erythropoiesis in sickle cell anemia and other related disorders, particularly in relation to hydroxyurea treatment.
  • Evaluated iron and ineffective erythropoiesis biomarkers in patients with sickle cell anemia and other red cell disorders.
  • Measured serum biomarkers including hepcidin, ferritin, GDF-15, and sTfR using ELISA.
  • Examined 12 SCA patients pre- and post-hydroxyurea treatment, and compared with patients having CD-II and HX.
  • Hepcidin/ferritin ratio was lower in SCA patients compared to controls, indicating iron dysregulation.
  • Hydroxyurea treatment improved the hepcidin/ferritin ratio in SCA patients.
  • ERFE levels were elevated in SCA and other disorders, reflecting increased erythropoiesis.

Cite This Study

Russell E. Ware (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dad7https://doi.org/10.1182/blood-2025-4686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease2025
  2. 2Serum Erythroferrone, a Biomarker of Erythropoietic Activity in End-Stage Renal Disease Patients2024
  3. 3Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia2025 · 1 citations
  4. 4Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea2025
  5. 5Real-world comparative effects of curative and disease-modifying therapies on ineffective erythropoiesis in beta-thalassemia2025