Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia

View Full Paper
Ask AI
Bookmark
Share

Authors

LHLubna HamdanYEYasmin El-GammalASAmy Shova

Discussion

Loading...

Member takes

Overview

Prospective study evaluates biomarkers like hepcidin and growth differentiation factor-15 to optimize transfusion in thalassemia patients, suggesting individualized Hb targets may reduce iron overload

Key Points

  • To explore the relationship between biomarkers of ineffective erythropoiesis and iron overload in transfusion-dependent thalassemia.
  • Longitudinal collection of pre-transfusion samples from patients with transfusion-dependent thalassemia.
  • Measured biomarkers included erythroferrone, growth differentiation factor-15, and hepcidin using ELISA.
  • Statistical analyses included Spearman correlation coefficients and linear mixed-effects models.
  • Significant negative correlation found between hemoglobin and erythroferrone (r=-0.36, P=0.02).
  • Erythroferrone variability explained mainly by differences between patients (ICC=0.9).
  • Identified stronger associations of erythroferrone and GDF-15 with hepcidin suppression compared to hemoglobin.

Cite This Study

Hamdan et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dad6https://doi.org/10.1182/blood-2025-4684
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron overload across the spectrum of non‐transfusion‐dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions2016 · 62 citations
  2. 2Real-world comparative effects of curative and disease-modifying therapies on ineffective erythropoiesis in beta-thalassemia2025
  3. 3MPACT OF IRON OVERLOAD AND HAMETOLOGICAL IN TRANSFUSION DEPENDENT THALSSEMIA PATIENTS2024
  4. 4Serum Erythroferrone Level and Its Relation to Iron Overload in Patients with Βeta-Thalassemia2026 · 1 citations
  5. 5Comparative Analysis of Erythroferrone and Hepcidin as Emerging Biomarkers of Iron Homeostasis in Patients with β-Thalassemia Major: A Case-Control Study from Pakistan2026 · 1 citations