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March 30, 2026Journal of Applied HematologyOpen Access

Serum Erythroferrone Level and Its Relation to Iron Overload in Patients with Βeta-Thalassemia

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Authors

MSMoustafa SalamaHHH. HassabNBNashwa Balbaa

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Overview

This cross-sectional study investigates erythroferrone's link to iron overload in beta-thalassemia children, suggesting its role as a marker for erythropoietic activity.

Key Points

  • To explore circulating erythroferrone levels and their association with iron overload markers in beta-thalassemia children.
  • Conducted a cross-sectional study with 67 beta-thalassemic children and 20 healthy controls.
  • Measured serum erythroferrone and hepcidin levels using ELISA.
  • Assessed iron overload through serum ferritin and MRI imaging of liver and cardiac iron.
  • Median ERFE levels were significantly elevated in both transfusion-dependent (287.26 ng/L) and non-transfusion-dependent (283.96 ng/L) groups compared to controls (100.53 ng/L).
  • A strong inverse correlation was found between ERFE and serum hepcidin levels in both beta-thalassemia groups.
  • No consistent associations were identified between ERFE and iron overload markers like ferritin or MRI-derived iron measurements.

Cite This Study

Salama et al. (2026) studied this question.

synapsesocial.com/papers/69ca134b883daed6ee0953e8https://doi.org/10.4103/joah.joah_10_26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Analysis of Erythroferrone and Hepcidin as Emerging Biomarkers of Iron Homeostasis in Patients with β-Thalassemia Major: A Case-Control Study from Pakistan2026 · 1 citations
  2. 2Erythroferrone and hepcidin levels in children with iron deficiency anemia2024 · 10 citations
  3. 3Association Between Serum Ferritin Level and Liver Function Tests in Children with Beta-Thalassemia (Thalassemia Center of Kut Hospital, Iraq)2024
  4. 4Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia2025 · 1 citations
  5. 5ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND LIVER FUNCTION TESTS IN CHILDREN WITH BETA-THALASSEMIAIN THALASSEMIA CENTER OF KUT HOSPITAL2024