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This research aims to evaluate the predictive value of specific serum miRNAs for CAR-T cell therapy outcomes in large B-cell lymphoma.

December 8, 2025BloodOpen Access

Serum mirnas predict response to CAR-T cell therapy in large B-cell lymphoma

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Retrospective study shows miRNAs predict CAR-T response in large B-cell lymphoma, suggesting improved outcomes.

This research aims to evaluate the predictive value of specific serum miRNAs for CAR-T cell therapy outcomes in large B-cell lymphoma.
Conducted a retrospective study with 22 patients diagnosed with R/R LBCL.
Evaluated serum samples for miRNA expression using digital PCR before CAR-T therapy.
Utilized predictive models to assess efficacy and prognosis using AUC and Kaplan-Meier analysis.
63.6% of patients had refractory disease; median PFS was significantly higher in the complete response group.
AUC for the 4-miRNA predictive model demonstrated strong predictive capability, especially at M3 and M6.
Median PFS was notably extended for responders compared to non-responders at M3 and M6 assessments.

Sheng et al. (2025) studied this question.

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