What question did this study set out to answer?

To explore the role of endothelial extracellular vesicles in the vascular dysfunction of sickle cell disease.

December 8, 2025BloodOpen Access

Circulating endothelial extracellular vesicles from sickle cell patients promote susceptibility of pulmonary endothelium to thrombotic injury

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Authors

SGSowmya Shree GopalThomas Jefferson University KMKatie McDonnellThomas Jefferson University SRSanaa RizkThomas Jefferson University

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Implication

This research reveals endothelial extracellular vesicles promote vascular dysfunction in sickle cell disease, indicating potential targets for thrombotic injury prevention.

Key Points

To explore the role of endothelial extracellular vesicles in the vascular dysfunction of sickle cell disease.
Isolated endothelial EVs from SCD patients and healthy controls
Assessed sizes and structural integrity via transmission electron microscopy and nanoparticle tracking analysis
Evaluated effects on human pulmonary microvascular endothelial cells under thrombotic stress
HbSS-derived EVs significantly decreased TEER under thrombin stimulation compared to healthy controls
Endothelial EVs from HbSS increased ICAM-1 and VCAM-1 expression, enhancing pro-inflammatory signaling
Distinct differences in EV properties were observed based on SCD subtype, with HbSS showing the highest pro-inflammatory activity.

Cite This Study

Gopal et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236daed https://doi.org/10.1182/blood-2025-4713

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Implication

This research reveals endothelial extracellular vesicles promote vascular dysfunction in sickle cell disease, indicating potential targets for thrombotic injury prevention.

Circulating endothelial extracellular vesicles from sickle cell patients promote susceptibility of pulmonary endothelium to thrombotic injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Circulating endothelial extracellular vesicles from sickle cell patients promote susceptibility of pulmonary endothelium to thrombotic injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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