Why the study?
Extracellular vesicles may contribute to systemic sclerosis onset via vascular function modulation, but available data are contradictory.
Do circulating extracellular vesicles from systemic sclerosis patients induce vascular dysfunction in endothelial and smooth muscle cells?
Comparison
EVs from complicated SSc vs uncomplicated SSc vs healthy controls
Design
In vitro translational study
Authors
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SSc EVs show distinct cellular markers and size; leaves open pathogenic role in vascular dysfunction pending prospective studies.
Do circulating extracellular vesicles from systemic sclerosis patients induce vascular dysfunction in endothelial and smooth muscle cells?
Circulating extracellular vesicles from systemic sclerosis patients exhibit a specific pathogenic profile that directly induces dysfunction in endothelial and smooth muscle cells.
Grossini et al. (2025) studied this question.
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