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December 8, 2025Blood

Deciphering tph cells as prognostic drivers of angioimmunoblastic T-cell lymphoma

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Authors

HYHaiyan YangJXJieyu XuXWXinchen Wang

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Overview

This analysis reveals immune dysregulation and poor progression-free survival in angioimmunoblastic T-cell lymphoma, highlighting Tph cells' role.

Key Points

  • To investigate the prognostic significance of Tph cells in angioimmunoblastic T-cell lymphoma (AITL).
  • Integrated CyTOF, scRNA-seq, and multi-immunofluorescence (mIF) analyses of peripheral blood and tumor samples.
  • Analyzed PBMCs from 17 AITL patients using a 42-marker CyTOF panel and scRNA-seq of 35,546 single cells.
  • Conducted pseudotime and cell-cell communication analyses to identify Tph cells' roles.
  • Identified Tph cells as a distinct subset enriched in AITL with a strong correlation to poorer progression-free survival.
  • Showed immune dysregulation mediated by CD70 and IL-21 signaling pathways.
  • Confirmed Tph cell infiltration in patients with adverse outcomes through mIF analysis.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db10https://doi.org/10.1182/blood-2025-5305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative profiling of t-follicular helper cells heterogeneity and tumor microenvironment signatures in angioimmunoblastic T cell lymphoma2025
  2. 2Integrating genomic and transcriptome features for characterization and prognostic prediction of angioimmunoblastic T-cell lymphoma2025
  3. 3166 Xenium-based in situ spatial transcriptomics identifies poor prognostic markers in relapsed angioimmunoblastic T-cell lymphoma2025
  4. 4Single-cell transcriptomic mapping of immune heterogeneity across angioimmunoblastic T-cell lymphoma subtypes2026
  5. 5Xenium‐based spatial transcriptomic analyses uncover prognosis‐associated heterogeneity in the tumor microenvironment ( <scp>TME</scp> ) of angioimmunoblastic T‐cell lymphoma ( <scp>AITL</scp> )2026