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December 8, 2025BloodOpen Access

Integrative profiling of t-follicular helper cells heterogeneity and tumor microenvironment signatures in angioimmunoblastic T cell lymphoma

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Authors

TSTania P SainzVMVakul MohantyXGXingmin Gui

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Overview

Single-cell RNA sequencing reveals mitochondrial metabolism and CD40 signatures in angioimmunoblastic T-cell lymphoma, indicating diagnostic complexities.

Key Points

  • This research aims to define the cellular and molecular characteristics of angioimmunoblastic T-cell lymphoma (AITL) and its tumor microenvironment.
  • Performed single-cell RNA sequencing on AITL lymph node specimens to analyze cellular composition.
  • Identified malignant T follicular helper cells using a panel of TFH-specific genes and scRepertoire for T-cell receptor analysis.
  • Used forty-plex immunofluorescence to study the lymphoma microenvironment context in AITL and reactive lymph nodes.
  • Neoplastic TFH cells showed altered mitochondrial metabolism and characteristics related to central memory cells.
  • Distinct microenvironment archetypes were identified in AITL with differential localization of CD40 expression.
  • CD40 expression was elevated in AITL and other T-cell lymphomas, suggesting its potential role as a biomarker.

Cite This Study

Sainz et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc93https://doi.org/10.1182/blood-2025-555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering tph cells as prognostic drivers of angioimmunoblastic T-cell lymphoma2025
  2. 2Integrating genomic and transcriptome features for characterization and prognostic prediction of angioimmunoblastic T-cell lymphoma2025
  3. 3Single-cell transcriptomic mapping of immune heterogeneity across angioimmunoblastic T-cell lymphoma subtypes2026
  4. 4166 Xenium-based in situ spatial transcriptomics identifies poor prognostic markers in relapsed angioimmunoblastic T-cell lymphoma2025
  5. 5Xenium‐based spatial transcriptomic analyses uncover prognosis‐associated heterogeneity in the tumor microenvironment ( <scp>TME</scp> ) of angioimmunoblastic T‐cell lymphoma ( <scp>AITL</scp> )2026