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December 8, 2025BloodOpen Access

Comprehensive analysis of early ctdna kinetics following first cycle of R-CHOP in LBCL patients

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Authors

PRPhilippe RuminyInsermJPJuliette PénichouxLaboratoire National Henri BecquerelAMAnne MenardLaboratoire National Henri Becquerel

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Overview

Comprehensive analysis reveals ctDNA kinetics and genomic instability in LBCL patients after R-CHOP, suggesting early detection of poor responders.

Key Points

  • This research aims to analyze early ctDNA kinetics and explore its prognostic value in LBCL patients treated with R-CHOP.
  • Conducted a prospective clinical trial (LYMPHOCLEAR) with 24 LBCL patients receiving first-line R-CHOP.
  • Collected ctDNA samples at multiple timepoints (H0, H4, H8, H12, H16, H24, H48) after R-CHOP.
  • Applied latent class mixed model to categorize ctDNA kinetics and identify patient classes based on their trajectories.
  • Identified four distinct classes of ctDNA kinetics based on patients' baseline values and changes over 48 hours.
  • Confirmed correlation between ctDNA quantity at C2D1 and patient response, as well as suggesting impact of ctDNA values at H4.
  • Showed that ctDNA quantity and variant allele frequencies can lead to potential early detection of poor responders.

Cite This Study

Ruminy et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1fhttps://doi.org/10.1182/blood-2025-5319
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